Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata

Carroll, A, Urban, S, Lamb, J, Moni, R, Guymer, G, Forster, P and Quinn, R 2008, 'Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata', Journal of Natural Products, vol. 71, no. 5, pp. 881-883.


Document type: Journal Article
Collection: Journal Articles

Title Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata
Author(s) Carroll, A
Urban, S
Lamb, J
Moni, R
Guymer, G
Forster, P
Quinn, R
Year 2008
Journal name Journal of Natural Products
Volume number 71
Issue number 5
Start page 881
End page 883
Total pages 3
Publisher American Chemical Society
Abstract High-throughput screeing of a plant and marine invertebrate extract library to find natural products with rat thytotropin releasing hormone receptor 2 binding affinity led to the isolation of two new active acylphloroglucinols, corymbones A and B (1 and 2) from flowers of the Queensland tree Corymbia peltata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 showed rat TRH receptor 2 binding affinity with IC50 values of 23 and 19 mu M, respectively.
Subject Biochemistry and Cell Biology not elsewhere classified
DOI - identifier 10.1021/np0706567
ISSN 0163-3864
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