The hemostatic defect of cardiopulmonary bypass

Linden, M 2003, 'The hemostatic defect of cardiopulmonary bypass', Journal of Thrombosis and Thrombolysis, vol. 16, no. 3, pp. 129-147.


Document type: Journal Article
Collection: Journal Articles

Title The hemostatic defect of cardiopulmonary bypass
Author(s) Linden, M
Year 2003
Journal name Journal of Thrombosis and Thrombolysis
Volume number 16
Issue number 3
Start page 129
End page 147
Total pages 19
Publisher Springer
Abstract Cardiac surgery involving cardiopulmonary bypass is a common yet complex procedure that results in considerable disruption of hemostasis during and following surgery. Despite the relatively common and widespread use of this procedure, there remains a significant peri-operative risk of both thrombosis and hemorrhage in some patients. This is known as the hemostatic defect of cardiopulmonary bypass. Strategies including the use of pharmacological agents, hemodilution, autologous blood transfusion, rapid in-theatre monitoring of hemostatic potential with fine-tuning of the degree of heparinization, minimally invasive surgery and the use of biologically coated cardiopulmonary bypass equipment have been employed to ameliorate the effects of cardiopulmonary bypass on hemostasis. However there exists a fine line between preventing hemorrhage and promoting thrombosis. Likewise attempts to prevent thrombosis may result in increased hemorrhage. Research into many strategies for minimizing the hemostatic defect of cardiopulmonary bypass is incomplete, with safety and efficacy the subjects of intensive investigation.
DOI - identifier 10.1023/B:THRO.0000024051.12177.e9
ISSN 0929-5305
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