Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy

Wilson, A, Swan, J, Ding, H, Zhang, Y, Whitbourn, R, Gurry, J, Yii, M, Wilson, A, Hill, M, Triggle, C, Best, J and Jenkins, A 2007, 'Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy', Atherosclerosis, vol. 191, pp. 175-181.


Document type: Journal Article
Collection: Journal Articles

Title Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy
Author(s) Wilson, A
Swan, J
Ding, H
Zhang, Y
Whitbourn, R
Gurry, J
Yii, M
Wilson, A
Hill, M
Triggle, C
Best, J
Jenkins, A
Year 2007
Journal name Atherosclerosis
Volume number 191
Start page 175
End page 181
Total pages 7
Publisher Elsevier Ireland
Abstract Objectives: Evidence of local vascular production and a relationship between serum hsCRP levels and tissue expression of CRP in subjects with vascular disease would support a direct role for CRP in atherosclerosis. Methods and results: Vascular tissue from subjects undergoing coronary artery bypass grafting surgery (CABGS) (n = 28) and carotid endarterectomy (CEA) (n = 25) were studied. Histological samples were assessed for intima-media ratio (IMR) and CRP by immunohistochemistry. CRP mRNA was quantified by real-time polymerase chain reaction. CRP mRNA was seen in all plaques, non-atherosclerotic artery and atrium but no difference in mRNA expression was seen between plaque and non-atherosclerotic tissue. Serum hsCRP correlated with IMR (r = 0.64, p = 0.001) in non-atherosclerotic arteries and with plaque CRP staining (r = 0.57, p = 0.009) independent of age, BMI, lipids, diabetes and blood pressure. In a separate patient series, serum hsCRP was measured in aortic and coronary sinus blood from subjects undergoing CABGS or angiography (n = 54). There was a coronary circulation hsCRP gradient ([mean ± S.E.M.] aortic CRP 4.3 mg/l ± 0.8 versus coronary sinus 5.8 ± 1.2 mg/l, p < 0.05). Conclusions: Widespread vascular CRP mRNA expression, a correlation between serum hsCRP, intimal hypertrophy and plaque CRP, and a coronary hsCRP gradient suggest vascular secretion may contribute to serum CRP levels.
Subject Cell Physiology
Keyword(s) Inflammatory Cytokines
Apoptotic Cells
Coronary Plaque
Smooth-Muscle
Plasma-Levels
Atherosclerosis
Interleukin-6
Association
Cholesterol
Restenosis
DOI - identifier 10.1016/j.atherosclerosis.2006.03.034
ISSN 0021-9150
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