Recapitulation of the parathyroid hormone-related peptide-indian hedgehog pathway in the regenerating deer antler

Faucheux, C, Nicholls, B, Allen, S, Danks, J, Horton, M and Price, J 2004, 'Recapitulation of the parathyroid hormone-related peptide-indian hedgehog pathway in the regenerating deer antler', Developmental Dynamics, vol. 231, no. 1, pp. 88-97.


Document type: Journal Article
Collection: Journal Articles

Title Recapitulation of the parathyroid hormone-related peptide-indian hedgehog pathway in the regenerating deer antler
Author(s) Faucheux, C
Nicholls, B
Allen, S
Danks, J
Horton, M
Price, J
Year 2004
Journal name Developmental Dynamics
Volume number 231
Issue number 1
Start page 88
End page 97
Total pages 10
Publisher John Wiley and Sons
Abstract Parathyroid hormone (PTH)-related peptide (PTHrP) and the PTH/PTHrP receptor (PPR) play an essential role in controlling growth plate development. The aim of the present study was to use the deer antler as a model to determine whether PTHrP and PPR may also have a function in regulating cartilage and bone regeneration in an adult mammal. Antlers are the only mammalian appendages that are able to undergo repeated cycles of regeneration, and their growth from a blastema involves a modified endochondral process. Immunohistochemistry was used to establish sites of localization of PTHrP and PPR in antlers at different stages of development. The pattern of Indian Hedgehog (IHH) and transforming growth factor-beta1 (TGF1) distribution was also investigated, because PTHrP expression in the developing limb is regulated by IHH and during embryonic growth plate formation TGF1 acts upstream of PTHrP to regulate the rate of chondrocyte differentiation. In the antler blastema (<10 days of development), PTHrP, PPR, and TGF1 were localized in epidermis, dermis, regenerating epithelium, and in mesenchymal cells but IHH expression was not detected. In the rapidly growing antler (weeks 4-8 of development), PTHrP, PPR, and TGF 1 were localized in skin, perichondrium, undifferentiated mesenchyme, recently differentiated chondrocytes, and in perivascular cells in cartilage but not in fully differentiated hyperytrophic chondrocytes.
Subject Endocrinology
DOI - identifier 10.1002/dvdy.20117
Copyright notice © 2004 Wiley-Liss, Inc.
ISSN 1058-8388
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