The molecular bases of training adaptation

Coffey, V and Hawley, J 2007, 'The molecular bases of training adaptation', Sports Medicine, vol. 37, no. 9, pp. 737-763.


Document type: Journal Article
Collection: Journal Articles

Title The molecular bases of training adaptation
Author(s) Coffey, V
Hawley, J
Year 2007
Journal name Sports Medicine
Volume number 37
Issue number 9
Start page 737
End page 763
Total pages 27
Publisher Adis International
Abstract Skeletal muscle is a malleable tissue capable of altering the type and amount of protein in response to disruptions to cellular homeostasis. The process of exercise-induced adaptation in skeletal muscle involves a multitude of signalling mechanisms initiating replication of specific DNA genetic sequences, enabling subsequent translation of the genetic message and ultimately generating a series of amino acids that form new proteins. The functional consequences of these adaptations are determined by training volume, intensity and frequency, and the half-life of the protein. Moreover, many features of the training adaptation are specific to the type of stimulus, such as the mode of exercise. Prolonged endurance training elicits a variety of metabolic and morphological changes, including mitochondrial biogenesis, fast-to-slow fibre-type transformation and substrate metabolism. In contrast, heavy resistance exercise stimulates synthesis of contractile proteins responsible for muscle hypertrophy and increases in maximal contractile force output. Concomitant with the vastly different functional outcomes induced by these diverse exercise modes, the genetic and molecular mechanisms of adaptation are distinct. With recent advances in technology, it is now possible to study the effects of various training interventions on a variety of signalling proteins and early-response genes in skeletal muscle.
Subject Exercise Physiology
Copyright notice © 2007 Adis Data Information BV. All rights reserved.
ISSN 0112-1642
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