High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine

Pedersen, D, Lessard, S, Coffey, V, Churchley, E, Wootton, A, Ng, T, Watt, M and Hawley, J 2008, 'High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine', Journal of Applied Physiology, vol. 105, no. 1, pp. 7-13.


Document type: Journal Article
Collection: Journal Articles

Title High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine
Author(s) Pedersen, D
Lessard, S
Coffey, V
Churchley, E
Wootton, A
Ng, T
Watt, M
Hawley, J
Year 2008
Journal name Journal of Applied Physiology
Volume number 105
Issue number 1
Start page 7
End page 13
Total pages 7
Publisher American Physiological Society
Abstract We determined the effect of coingestion of caffeine (Caff) with carbohydrate (CHO) on rates of muscle glycogen resynthesis during recovery from exhaustive exercise in seven trained subjects who completed two experimental trials in a randomized, double-blind crossover design. The evening before an experiment subjects performed intermittent exhaustive cycling and then consumed a low-CHO meal. The next morning subjects rode until volitional fatigue. On completion of this ride subjects consumed either CHO [4 g/kg body mass (BM)] or the same amount of CHO + Caff (8 mg/kg BM) during 4 h of passive recovery. Muscle biopsies and blood samples were taken at regular intervals throughout recovery. Muscle glycogen levels were similar at exhaustion [75 mmol/kg dry wt (dw)] and increased by a similar amount (80%) after 1 h of recovery (133 ± 37.8 vs. 149 ± 48 mmol/kg dw for CHO and Caff, respectively). After 4 h of recovery Caff resulted in higher glycogen accumulation (313 ± 69 vs. 234 ± 50 mmol/kg dw, P < 0.001). Accordingly, the overall rate of resynthesis for the 4-h recovery period was 66% higher in Caff compared with CHO (57.7 ± 18.5 vs. 38.0 ± 7.7 mmol·kg dw-1·h-1, P < 0.05). After 1 h of recovery plasma Caff levels had increased to 31 ± 11 μM (P < 0.001) and at the end of the recovery reached 77 ± 11 μM (P < 0.001) with Caff. Phosphorylation of CaMKThr286 was similar after exercise and after 1 h of recovery, but after 4 h CaMKThr286 phosphorylation was higher in Caff than CHO (P < 0.05). Phosphorylation of AMP-activated protein kinase (AMPK)Thr172 and AktSer473 was similar for both treatments at all time points. We provide the first evidence that in trained subjects coingestion of large amounts of Caff (8 mg/kg BM) with CHO has an additive effect on rates of postexercise muscle glycogen accumulation compared with consumption of CHO alone.
Subject Exercise Physiology
DOI - identifier 10.1152/japplphysiol.01121.2007
Copyright notice © 2008 the American Physiological Society
ISSN 8750-7587
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 60 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 56 times in Scopus Article | Citations
Altmetric details:
Access Statistics: 186 Abstract Views  -  Detailed Statistics
Created: Wed, 22 Dec 2010, 10:15:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us