Sulfa drugs strike more than once

Patel, O, Mberu, E, Nzila, A and Macreadie, I 2004, 'Sulfa drugs strike more than once', Trends in Parasitology, vol. 20, no. 1, pp. 1-3.


Document type: Journal Article
Collection: Journal Articles

Title Sulfa drugs strike more than once
Author(s) Patel, O
Mberu, E
Nzila, A
Macreadie, I
Year 2004
Journal name Trends in Parasitology
Volume number 20
Issue number 1
Start page 1
End page 3
Total pages 3
Publisher Elsevier
Abstract Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that they can also condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate to form sulfa-dihydropteroate (sulfa-DHP), which are inhibitory through competition with dihydrofolate. This suggests that, in addition to dihydropteroate synthase, there are still undiscovered determinants involved in sulfa drug resistance. Furthermore, novel drugs based on the DHP analogues could be added to the armory of antifolate drugs.
Subject Mineral Processing/Beneficiation
Keyword(s) sulfa drugs
folate synthesis
dihydropteroate synthase
DHP analogues
antifolate drugs
DOI - identifier 10.1016/j.pt.2003.10.009
Copyright notice © 2003 Elsevier Ltd.
ISSN 1471-4922
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