Activation of spinally projecting and nitrergic neurons in the PVN following heat exposure

Cham, J, Klein, R, Owens, N, Mathai, M, McKinley, M and Badoer, E 2006, 'Activation of spinally projecting and nitrergic neurons in the PVN following heat exposure', American Journal of Physiology: Regulatory Integrative and Comparative Physiology, vol. 291, pp. R91-R101.


Document type: Journal Article
Collection: Journal Articles

Title Activation of spinally projecting and nitrergic neurons in the PVN following heat exposure
Author(s) Cham, J
Klein, R
Owens, N
Mathai, M
McKinley, M
Badoer, E
Year 2006
Journal name American Journal of Physiology: Regulatory Integrative and Comparative Physiology
Volume number 291
Start page R91
End page R101
Total pages 11
Publisher American Physiological Society
Abstract The present study investigated the effect of acute thermal stimulation in conscious rats on the production of Fos, a marker of increased neuronal activity, in spinally projecting and nitrergic neurons in the hypothalamic paraventricular nucleus (PVN). The PVN contains a high concentration of nitrergic neurons, as well as neurons that project to the intermediolateral cell column (IML) of the spinal cord that can directly influence sympathetic nerve activity (SNA). During thermal stimulation, the PVN is activated, but it is unknown whether spinally projecting PVN neurons and the nitrergic neurons are involved. Compared with controls, rats exposed to an environmental temperature of 39 degrees C for 1 h had a 10-fold increase in the number of cells producing Fos in the PVN (133 +/- 23 vs. 1,336 +/- 43, respectively, P < 0.0001). Of the spinally projecting neurons in the PVN of heated rats (98 +/- 10), over 20% expressed Fos. Additionally, of the nitrergic neurons (NADPH-diaphorase positive) located in the parvocellular PVN (723 +/- 17), similar to 40% also expressed Fos (P < 0.0001 compared with controls). Finally, there was a significant increase in the number of spinally projecting neurons in the PVN that were nitrergic and expressed Fos after heat exposure (12%) compared with controls (0.1%) (P < 0.0001). These results suggest that spinally projecting and nitrergic neurons in the PVN may contribute to the central pathways activated by thermal stimulation.
Subject Medical Physiology not elsewhere classified
Keyword(s) Nitric-Oxide Synthase
C-Fos Expression
Hypothalamic Paraventricular Nucleus
Thermoregulatory Vasomotor Control
Corticotropin-Releasing Factor
Rostral Ventrolateral Medulla
Brown Adipose-Tissue
Rat-Brain
Gene-Expression
Temperature Regulation
DOI - identifier 10.1152/ajpregu.00675.2005
Copyright notice © 2006 American Physiological Society
ISSN 0363-6119
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