Does perinatal omega-3 polyunsaturated fatty acid deficiency increase appetite signaling?

Mathai, M, Soueid, M, Chen, N, Jayasooriya, A, Sinclair, A, Wlodek, M, Weisinger, H and Weisinger, R 2004, 'Does perinatal omega-3 polyunsaturated fatty acid deficiency increase appetite signaling?', Obesity, vol. 12, pp. 1886-1894.


Document type: Journal Article
Collection: Journal Articles

Title Does perinatal omega-3 polyunsaturated fatty acid deficiency increase appetite signaling?
Author(s) Mathai, M
Soueid, M
Chen, N
Jayasooriya, A
Sinclair, A
Wlodek, M
Weisinger, H
Weisinger, R
Year 2004
Journal name Obesity
Volume number 12
Start page 1886
End page 1894
Total pages 9
Publisher North American Association for the Study of Obesity
Abstract OBJECTIVE - To investigate the effect of maternal dietary omega-3 polyunsaturated fatty acid (PUFA) deficiency and repletion on food appetite signaling. RESEARCH METHODS & PROCEDURES - Sprague-Dawley rat dams were maintained on diets,either supplemented with (CON) or deficient in (DEF) omega-3 PUFA. All offspring were raised on the maternal diet until weaning. After weaning, two groups remained on the respective maternal diet (CON and DEF groups), whereas a third group, born of dams fed the DEF diet, were switched to the CON diet (REC). Experiments on food intake began when the male rats reached 16 weeks of age. Food intake was stimulated either by a period of food restriction, by blocking glucose utilization (by 2-deoxyglucose injection), or by blocking beta-oxidation of fatty acids (by beta-mercaptoacetate injection). RESULTS - DEF animals consumed more than CON animals in response to all stimuli, with the greatest difference (1.9-fold) demonstrated following administration of 2-deoxyglucose. REC animals also consumed more than CON animals in response to food restriction and 2-deoxyglucose but not to beta-mercaptoacetate. DISCUSSION - These findings indicate that supply of omega-3 PUFA, particularly during the perinatal period, plays a role in the normal development of mechanisms controlling food intake, especially glucoprivic (i.e. reduced glucose availability) appetite signaling. Dietary repletion of omega-3 PUFA from 3 weeks of age restored intake responses to fatty acid metabolite signaling but did not reverse those in response to food restriction or glucoprivic stimuli.
Subject Nutrition and Dietetics not elsewhere classified
Keyword(s) Fatty acids
appetite signalling
DOI - identifier 10.1038/oby.2004.234
ISSN 1071-7323
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