17-beta-Estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle

Campbell, S, Mehan, K, Tunstall, R, Febbraio, M and Cameron-Smith, D 2003, '17-beta-Estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle', Journal of Molecular Endocrinology, vol. 31, no. 1, pp. 37-45.


Document type: Journal Article
Collection: Journal Articles

Title 17-beta-Estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle
Author(s) Campbell, S
Mehan, K
Tunstall, R
Febbraio, M
Cameron-Smith, D
Year 2003
Journal name Journal of Molecular Endocrinology
Volume number 31
Issue number 1
Start page 37
End page 45
Total pages 9
Publisher Society of Endocrinology
Abstract This study examined the actions of 17beta-estradiol (E(2)) and progesterone on the regulation of the peroxisome proliferator-activated receptors (PPARalpha and PPARgamma) family of nuclear transcription factors and the mRNA abundance of key enzymes involved in fat oxidation, in skeletal muscle. Specifically, carnitine palmitoyltransferase I (CPT I), beta-3-hydroxyacyl CoA dehydrogenase (beta-HAD), and pyruvate dehydrogenase kinase 4 (PDK4) were examined. Sprague-Dawley rats were ovariectomized and treated with placebo (Ovx), E(2), progesterone, or both hormones in combination (E+P). Additionally, sham-operated rats were treated with placebo (Sham) to serve as controls. Hormone (or vehicle only) delivery was via time release pellets inserted at the time of surgery, 15 days prior to analysis. E(2) treatment increased PPARalpha mRNA expression and protein content (P<0.05), compared with Ovx treatment. E(2) also resulted in upregulated mRNA of CPT I and PDK4 (P<0.05). PPARgamma mRNA expression was also increased (P<0.05) by E(2) treatment, although protein content remained unaltered. These data demonstrate the novel regulation of E(2) on PPARalpha and genes encoding key proteins that are pivotal in regulating skeletal muscle lipid oxidative flux
Subject Endocrinology
DOI - identifier 10.1677/jme.0.0310037
Copyright notice © 2003 Society for Endocrinology
ISSN 0952-5041
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