Effect of high-frequency resistance exercise on adaptive responses in skeletal muscle

Coffey, V, Reeder, D, Lancaster, G, Yeo, W, Febbraio, M, Yaspelkis, B and Hawley, J 2007, 'Effect of high-frequency resistance exercise on adaptive responses in skeletal muscle', Medicine and Science in Sports and Exercise, vol. 39, pp. 2135-2144.


Document type: Journal Article
Collection: Journal Articles

Title Effect of high-frequency resistance exercise on adaptive responses in skeletal muscle
Author(s) Coffey, V
Reeder, D
Lancaster, G
Yeo, W
Febbraio, M
Yaspelkis, B
Hawley, J
Year 2007
Journal name Medicine and Science in Sports and Exercise
Volume number 39
Start page 2135
End page 2144
Total pages 10
Publisher Lipincott Williams and Wilkins
Abstract PURPOSE: Regulation of skeletal muscle mass is highly dependent on contractile loading. The purpose of this study was to examine changes in growth factor and inflammatory pathways following high-frequency resistance training. Results: The stacked training regimen resulted in acute suppression of insulin-like growth factor 1 mRNA abundance (P < 0.05) and Aktser473 phosphorylation (P < 0.05), an effect that persisted 48 h after the final training bout. Conversely, stacked training elicited a coordinated increase in the expression of tumor necrosis factor alpha, inhibitor kappa B kinase alpha/beta activity (P < 0.05), and p38 mitogen-activated protein kinase phosphorylation (P < 0.05) at 3 h after each training bout. In addition, the stacked series of resistance exercise bouts induced an increase in p70 S6 kinasethr389 phosphorylation 3 h after bouts x3 and x4, independent of the phosphorylation state of Akt. CONCLUSIONS: Our results indicate that high resistance training frequency extends the transient activation of inflammatory signaling cascades, concomitant with persistent suppression of key mediators of anabolic responses. We provide novel insights into the effects of the timing of exercise-induced overload and recovery on signal transduction pathways and transcriptional activity regulating skeletal muscle mass in vivo.
Subject Exercise Physiology
Keyword(s) Necrosis-Factor-Alpha
Kappa-B Kinase
P70 S6 Kinase
Protein-Synthesis
Signaling Pathways
Cell-Cycle
Molecular Responses
Gene-Expression
Time-Course
P38 Mapk
DOI - identifier 10.1249/mss.0b013e31815729b6
Copyright notice © 2007 The American College of Sports Medicine
ISSN 0195-9131
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