Fibroblast differentiation in wound healing and fibrosis

Darby, I and Hewitson, T 2007, 'Fibroblast differentiation in wound healing and fibrosis', International Review of Cytology, vol. 257, pp. 143-179.


Document type: Journal Article
Collection: Journal Articles

Title Fibroblast differentiation in wound healing and fibrosis
Author(s) Darby, I
Hewitson, T
Year 2007
Journal name International Review of Cytology
Volume number 257
Start page 143
End page 179
Total pages 37
Publisher Academic Press
Abstract The contraction of granulation tissue from skin wounds was first described in the 1960s. Later it was discovered that during tissue repair, fibroblasts undergo a change in phenotype from their normal relatively quiescent state in which they are involved in slow turnover of the extracellular matrix, to a proliferative and contractile phenotype termed myofibroblasts. These cells show some of the phenotypic characteristics of smooth muscle cells and have been shown to contract in vitro. In the 1990s, a number of researchers in different fields showed that myofibroblasts are present during tissue repair or response to injury in a variety of other tissues, including the liver, kidney, and lung. During normal repair processes, the myofibroblastic cells are lost as repair resolves to form a scar. This cell loss is via apoptosis. In pathological fibroses, mycifibroblasts persist in the tissue and are responsible for fibrosis via increased matrix synthesis and for contraction of the tissue. In many cases this expansion of the extracellular matrix impedes normal function of the organ. For this reason much interest has centered on the derivation of myofibroblasts and the factors that influence their differentiation, proliferation, extracellular matrix synthesis, and survival. Further understanding of how fibroblast differentiation and myofibroblast phenotype is controlled may provide valuable insights into future therapies that can control fibrosis and scarring.
Subject Cell Physiology
Keyword(s) Actin
Apoptosis
Collagen
Fibroblast
Fibrosis
Myofibroblast
Wound healing
DOI - identifier 10.1016/S0074-7696(07)57004-X
Copyright notice © 2007 Elsevier Inc. All rights reserved.
ISSN 0074-7696
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