Role of p-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra

Yu, X, Lin, S, Zhou, Z, Chen, X, Liang, J, Yu, X, Chowbay, B, Wen, J, Duan, W, Chan, E, Li, X, Cao, J, Li, C, Xue, C and Zhou, S 2007, 'Role of p-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra', Pharmaceutical Research, vol. 24, no. 9, pp. 1668-1690.


Document type: Journal Article
Collection: Journal Articles

Title Role of p-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra
Author(s) Yu, X
Lin, S
Zhou, Z
Chen, X
Liang, J
Yu, X
Chowbay, B
Wen, J
Duan, W
Chan, E
Li, X
Cao, J
Li, C
Xue, C
Zhou, S
Year 2007
Journal name Pharmaceutical Research
Volume number 24
Issue number 9
Start page 1668
End page 1690
Total pages 23
Publisher Springer
Abstract PURPOSE - Glabridin is a major active constituent of Glycyrrhiza glabra which is commonly used in the treatment of cardiovascular and central nervous system (CNS) diseases. Recently, we have found that glabridin is a substrate of P-glycoprotein (PgP/MDR1). This study aimed to investigate the role of PgP in glabridin penetration across the blood-brain barrier (BBB) using several in vitro and in vivo models. MATERIALS AND METHODS - Cultured primary rat brain microvascular endothelial cells (RBMVECs) were used in the uptake, efflux and transcellular transport studies. A rat bilateral in situ brain perfusion model was used to investigate the brain distribution of glabridin. The brain and tissue distribution of glabridin in rats with or without coadministered verapamil or quinidine were examined with correction for the tissue residual blood. In addition, the brain distribution of glabridin in mdrla(-/-) mice was compared with the wild-type mice. Glabridin in various biological matrices was determined by a validated liquid chromatography mass spectrometric method.
Subject Basic Pharmacology
Keyword(s) Intentinal-Absorption
Efflux Transporters
Endothelial-Cells
Abc Transporters
Drug Trabsport
Blood
barrier
Licorice
Vanblastine
Health
DOI - identifier 10.1007/s11095-007-9297-1
Copyright notice © 2007 Springer Science + Business Media, Inc
ISSN 0724-8741
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