Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice

Ceroni, L, Ellis, A, Wiehler, W, Jiang, Y, Ding, H and Triggle, C 2007, 'Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice', European Journal of Pharmacology, vol. 560, no. 23, pp. 193-200.


Document type: Journal Article
Collection: Journal Articles

Title Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice
Author(s) Ceroni, L
Ellis, A
Wiehler, W
Jiang, Y
Ding, H
Triggle, C
Year 2007
Journal name European Journal of Pharmacology
Volume number 560
Issue number 23
Start page 193
End page 200
Total pages 8
Publisher Elsevier Science
Abstract Endothelium-derived hyperpolarizing factor (EDHF), notably in the microcirculation, plays an important role in the regulation of vascular tone. The cellular events that mediate EDHF are critically dependent, in a vessel dependent manner, on small conductance calcium-activated potassium channels (SK) and intermediate conductance calcium-activated potassium channels (IK) as well as the presence of the gap junction connexins 37,40, and 43. We hypothesized that the expression levels of SK, IK, as well as vascular connexins, notably 37, 40 and 43 but, potentially, connexin 45, would show correlation with the contribution of EDHF to acetylcholine-mediated vasodilatation as well as, in the absence of endothelial-derived NO, higher expression levels in eNOS(-/-) mice. Wire myograph studies were performed to confirm the contribution of EDHF to endothelium-dependent relaxation in 1st, 2nd and 3rd order small mesenteric arteries from C57BL/6J eNOS-expressing (eNOS(+/+)) and eNOS-deficient C57BL/6J (eNOS(-/-)) mice.
Subject Cell Physiology
Keyword(s) Ca2+-Activated K+ Channel
Nitric Oxide Synthase
Endothelium Dependent Hyperpolarization
Acetylcholine-Induced Relaxation
Myoendothelial Gap-Junctions
Small Conductance
Coronary-Artery
Db/Db Mice
Ehdf
Rat
Copyright notice © 2007 Published by Elsevier B.V.
ISSN 0014-2999
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