Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants

Dusting, G and Triggle, C 2005, 'Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants', Vascular Health and Risk Management, vol. 1, no. 2, pp. 93-97.


Document type: Journal Article
Collection: Journal Articles

Title Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants
Author(s) Dusting, G
Triggle, C
Year 2005
Journal name Vascular Health and Risk Management
Volume number 1
Issue number 2
Start page 93
End page 97
Total pages 5
Publisher Dove Medical Press
Abstract A number of recent clinical trials with antioxidants, notably vitamin C and E, have provided no support for the commonly held view that increasing our intake of antioxidants will offset the ravages of cardiovascular disease as well as other diseases (for extensive critical reviews see: Kritharides and Stocker 2002; Antoniades et al 2003; Touyz 2004). Is this conclusion justified? The role of antioxidant dietary adjuncts and therapy in prevention and treatment remains a highly important clinical question. In this opinion article we address the question: Is there a future for antioxidant therapy in the treatment and prevention of cardiovascular disease? We conclude that there is a need for better-designed studies as well as a re-thinking of the choice of antioxidants.
Subject Cardiology (incl. Cardiovascular Diseases)
Keyword(s) Cardiovascular Disease
Anti-oxidants
DOI - identifier 10.2147/vhrm.1.2.93.64080
Copyright notice © 2005 Dove Medical Press Limited. All rights reserved
ISSN 1176-6344
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