Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: Assessing the health of the endothelium

Ding, H and Triggle, C 2005, 'Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: Assessing the health of the endothelium', Vascular Health and Risk Management, vol. 1, pp. 55-71.


Document type: Journal Article
Collection: Journal Articles

Title Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: Assessing the health of the endothelium
Author(s) Ding, H
Triggle, C
Year 2005
Journal name Vascular Health and Risk Management
Volume number 1
Start page 55
End page 71
Total pages 17
Publisher Dove Medical Press
Abstract Diabetes-associated vascular complications are collectively the major clinical problems facing patients with diabetes and lead to the considerably higher mortality rate than that of the general population. People with diabetes have a much higher incidence of coronary artery disease as well as peripheral vascular diseases in part because of accelerated atherogenesis. Despite the introduction of new therapies, it has not been possible to effectively reduce the high cardiovascular morbidity and mortality associated with diabetes. Of additional concern is the recognition by the World Health Organization that we are facing a global epidemic of type 2 diabetes. Endothelial dysfunction is an early indicator of cardiovascular disease, including that seen in type 2 diabetes. A healthy endothelium, as defined in terms of the vasodilator/blood flow response to an endothelium-dependent vasodilator, is an important indicator of cardiovascular health and, therefore, a goal for corrective interventions. In this review we explore the cellular basis for endothelial dysfunction in an attempt to identify appropriate new targets and strategies for the treatment of diabetes. In addition, we consider the question of biomarkers for vascular disease and evaluate their usefulness for the early detection of and their role as contributors to vascular dysfunction.
Subject Cardiology (incl. Cardiovascular Diseases)
Keyword(s) endothelium
diabetes
nitric oxide (NO)
C-reactive protein (CRP)
asymmetric dimethylarginine (ADMA)
endothelial progenitor cells (EPCs)
DOI - identifier 10.2147/vhrm.1.1.55.58939
Copyright notice © 2005 Dove Medical Press Limited. All rights reserved
ISSN 1176-6344
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