Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance

Lessard, S, Rivas, D, Chen, Z, Bonen, A, Febbraio, M, Reeder, D, Kemp, B, Yaspelkis, B and Hawley, J 2007, 'Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance', Diabetes, vol. 56, pp. 1856-1864.


Document type: Journal Article
Collection: Journal Articles

Title Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance
Author(s) Lessard, S
Rivas, D
Chen, Z
Bonen, A
Febbraio, M
Reeder, D
Kemp, B
Yaspelkis, B
Hawley, J
Year 2007
Journal name Diabetes
Volume number 56
Start page 1856
End page 1864
Total pages 9
Publisher American Diabetes Association
Abstract Both pharmacological intervention (i.e., thiazolidinediones [TZDs]) and lifestyle modification (i.e., exercise training) are clinically effective treatments for improving whole-body insulin sensitivity. However, the mechanism(s) by which these therapies reverse lipid-induced insulin resistance in skeletal muscle is unclear. We determined the effects of 4 weeks of rosiglitazone treatment and exercise training and their combined actions (rosiglitazone treatment and exercise training) on lipid and glucose metabolism in high-fat fed rats. High-fat feeding resulted in decreased muscle insulin sensitivity, which was associated with increased rates of palmitate uptake and the accumulation of the fatty acid metabolites ceramide and diacylglycerol. Impairments in lipid metabolism were accompanied by defects in the Akt/AS160 signaling pathway. Exercise training, but not rosiglitazone treatment, reversed these impairments, resulting in improved insulin-stimulated glucose transport and increased rates of fatty acid oxidation in skeletal muscle.
Subject Clinical Sciences not elsewhere classified
Keyword(s) Activated Protein-Kinase
Human Skeletal-Muscle
Type-2 Diabetic Subjects
Zucker Fatty Rats
Adipose-Tissue
Glucose-Uptake
Phosphatidylinositol 3-Kinase
Triglyceride Content
Acid Uptake
Metformin
DOI - identifier 10.2337/db06-1065
Copyright notice © 2007 American Diabetes Association
ISSN 0012-1797
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