Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes

Halls, M, Bathgate, R, Roche, P and Summers, R 2005, 'Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes', Annals of the New York Academy of Sciences, vol. 1041, pp. 292-295.


Document type: Journal Article
Collection: Journal Articles

Title Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes
Author(s) Halls, M
Bathgate, R
Roche, P
Summers, R
Year 2005
Journal name Annals of the New York Academy of Sciences
Volume number 1041
Start page 292
End page 295
Total pages 4
Publisher New York Academy of Sciences
Abstract Although much is known about the pleiotropic effects mediated by relaxin, the exact signaling pathways involved remain relatively elusive. This study examines LGR7 and LGR8 signaling using reporter gene technology. The greatest response was observed at the CRE reporter (indicates activation of cAMP-PKA and p38/JNK pathways), although INSL3 treatment of LGR8 produced a lower response than H2 relaxin treatment of LGR7. AP1 (which indicates activation of JNK pathways) was stimulated to a lesser degree. Three other reporters produced no response. The reporter gene studies suggest that ligand stimulation of LGR7 and LGR8 involves cAMP-PKA and p38/JNK signaling.
Subject Analytical Biochemistry
Keyword(s) signaling
reporter genes
relaxin
LGRs
DOI - identifier 10.1196/annals.1282.043
Copyright notice © 2005 New York Academy of Sciences
ISSN 0077-8923
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