Effects of gamma-tocopherol supplementation on thrombotic risk factors

Singh, I, Turner, A, Sinclair, A, Li, D and Hawley, J 2007, 'Effects of gamma-tocopherol supplementation on thrombotic risk factors', Asia Pacific Journal Of Clinical Nutrition, vol. 16, no. 3, pp. 422-428.


Document type: Journal Article
Collection: Journal Articles

Title Effects of gamma-tocopherol supplementation on thrombotic risk factors
Author(s) Singh, I
Turner, A
Sinclair, A
Li, D
Hawley, J
Year 2007
Journal name Asia Pacific Journal Of Clinical Nutrition
Volume number 16
Issue number 3
Start page 422
End page 428
Total pages 7
Publisher HEC Press
Abstract OBJECTIVE: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (alpha-T) and gammatocopherol (gamma-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using a-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d gamma-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). METHODS AND RESULTS: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of gamma-T and 12 received placebo (soybean capsules with less than 5 mg/d gamma-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood gamma-T concentrations increased significantly (p<0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p<0.05). Subjects consuming 100 mg/d gamma-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p<0.05), Little effect of gamma-T was observed on other parameters. CONCLUSIONS: These data suggest that gamma-T supplementation may have a permissive role in decreasing the risk of thrombotic events by improving lipid profile and reducing platelet activity.
Subject Haematology
Keyword(s) Low-Density-Lipoprotein
Clinical-Trial Data
Alpha-Tocopherol
Vitamin-E
Cardiovascular-Disease
Mixed Tocopherols
Antioxidant Vitamins
Heart-Disease
Plasma
Protein
ISSN 0964-7058
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