Exercise-induced phospho-proteins in skeletal muscle

Deshmukh, A, Hawley, J and Zierath, J 2008, 'Exercise-induced phospho-proteins in skeletal muscle', International Journal of Obesity, vol. 32, pp. 18-23.


Document type: Journal Article
Collection: Journal Articles

Title Exercise-induced phospho-proteins in skeletal muscle
Author(s) Deshmukh, A
Hawley, J
Zierath, J
Year 2008
Journal name International Journal of Obesity
Volume number 32
Start page 18
End page 23
Total pages 6
Publisher Nature Publishing Group
Abstract Efforts to identify exercise-induced signaling events in skeletal muscle have been influenced by ground-breaking discoveries in the insulin action field. Initial discoveries demonstrating that exercise enhances insulin sensitivity raised the possibility that contraction directly modulates insulin receptor signaling events. Although the acute effects of exercise on glucose metabolism are clearly insulin-independent, the canonical insulin signaling cascade has been used as a framework by investigators in an attempt to resolve the mechanisms by which muscle contraction governs glucose metabolism. This review focuses on recent advances in our understanding of exercise-induced signaling pathways governing glucose metabolism in skeletal muscle. Particular emphasis will be placed on the characterization of AS160, a novel Akt substrate that plays a role in the regulation of glucose transport.
Subject Clinical Sciences not elsewhere classified
Keyword(s) signal transduction
gluscose uptake
AKt
AMPK
AS160
ISSN 0307-0565
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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