The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats

Singh, M, Hodges, L, Wright, P, Cheah, D, Kalafatis, N, Wynne, P and Macrides, T 2008, 'The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats', Comparative Biochemistry and Physiology B: Biochemistry and Molecular Biology, vol. 149, no. 2, pp. 251-258.


Document type: Journal Article
Collection: Journal Articles

Title The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats
Author(s) Singh, M
Hodges, L
Wright, P
Cheah, D
Kalafatis, N
Wynne, P
Macrides, T
Year 2008
Journal name Comparative Biochemistry and Physiology B: Biochemistry and Molecular Biology
Volume number 149
Issue number 2
Start page 251
End page 258
Total pages 8
Publisher Elsevier
Abstract The anti-inflammatory (AI) activity of a supercritical fluid extract (CO2-SFE) of tartaric acid-stabilised Perna canaliculus mussel powder, and of the free fatty acid (FFA) class separated from the CO2-SFE extract by column chromatography, was investigated in the rat adjuvant arthritis model. Administration of the CO2-SFE extract (100 mg/kg BW/day s.c.) for 15 days post-adjuvant inoculation significantly reduced rear paw swelling by 34% and the deterioration in total body condition by 52% in arthritic rats, compared to vehicle controls. These observations were accompanied by a decreased serum ceruloplasmin oxidase activity, and reduced inflammatory response of the spleen. The mussel FFA extract given at one third of the dose (30 mg/kg BW/day s.c.) and for a shorter treatment period (5 days during the inflammatory phase) achieved an even greater AI activity, and was equipotent to piroxicam (2 mg/kg BW/day s.c.). Preliminary toxicology assessment using both arthritic and non-arthritic (healthy) rats revealed no significant differences between the mussel treatment groups and respective vehicle controls in either organ weights, tissue histology or selected biochemical parameters. These results indicate the CO2-SFE crude lipid extract and its FFA components from stabilised P. canaliculus mussel powder contain biologically significant AI activity in vivo, with no apparent adverse side effects.
Subject Basic Pharmacology
Keyword(s) Adjuvant arthritis
anti-inflammatory
perma canaliculus
3 PUFA
DOI - identifier 10.1016/j.cbpb.2007.09.015
Copyright notice Copyright © 2007 Elsevier Inc. All rights reserved.
ISSN 1096-4959
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
Altmetric details:
Access Statistics: 185 Abstract Views  -  Detailed Statistics
Created: Fri, 07 Jan 2011, 09:11:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us