Placental drug disposition and its clinical implications

Weier, N, He, S, Li, X, Wang, L and Zhou, S 2008, 'Placental drug disposition and its clinical implications', Current Drug Metabolism, vol. 9, no. 2, pp. 106-121.


Document type: Journal Article
Collection: Journal Articles

Title Placental drug disposition and its clinical implications
Author(s) Weier, N
He, S
Li, X
Wang, L
Zhou, S
Year 2008
Journal name Current Drug Metabolism
Volume number 9
Issue number 2
Start page 106
End page 121
Total pages 16
Publisher Bentham Science Publishers Ltd.
Abstract The placenta is a unique organ that is essential to a healthy and normal pregnancy. A number of phase I and II metabolizing enzymes are expressed at moderate levels in the placenta, and have been proven to have the ability to metabolize certain xenobiotics. Depending on the substrate, this metabolic action may have significant clinical implications on how it affects the fetus. A wide variety of transporters including P-glycoprotein, breast cancer resistance protein, and multidrug resistance associated proteins have also been discovered in the placenta, and while most are found to have mainly physiological substrates, there are a number of xenobiotics which are also able to gain access to the fetus through transport across the placenta. Depending on the xenobiotics and its intended action, drug transport across the placenta may be desired, acceptable or undesirable. Medications administered to the mother but designed to work on the fetus are now being used increasingly, and demonstrates an important clinical implication in which drug transport across the placenta is desirable. However, medications designed to treat the mother but are also able to cross the placenta carry potential risks to damage the developing fetus, and it is therefore essential that the effects of different drugs on the fetus are known before they are administered during pregnancy.
Keyword(s) Placenta
drug metabolism
drug transporter
cytochrome P450
P-glycoprotein
DOI - identifier 10.2174/138920008783571828
Copyright notice © 2008 Bentham Science Publishers
ISSN 1389-2002
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