AMP-activated protein kinase - the fat controller of the energy railroad

Steinberg, G, Macaulay, L, Febbraio, M and Kemp, B 2006, 'AMP-activated protein kinase - the fat controller of the energy railroad', Canadian Journal of Physiology and Pharmacology, vol. 84, pp. 655-665.


Document type: Journal Article
Collection: Journal Articles

Title AMP-activated protein kinase - the fat controller of the energy railroad
Author(s) Steinberg, G
Macaulay, L
Febbraio, M
Kemp, B
Year 2006
Journal name Canadian Journal of Physiology and Pharmacology
Volume number 84
Start page 655
End page 665
Total pages 11
Publisher National Research Council Canada
Abstract AMP-activated protein kinase plays an important role in the regulation of lipid metabolism in response to metabolic stress and energy demand. It is also under endocrine control. AMPK acts at multiple steps and has a central role controlling fatty acid, triglyceride, and cholesterol synthesis, as well as the oxidation of fatty acids through direct phosphorylation effects and the control of gene transcription. As such, it can be considered to be the fat controller of the energy railroad. It is thought that AMPK may be a major mediator of the health benefits of exercise in mitigating the development of obesity and age-onset diseases.
Subject Exercise Physiology
Keyword(s) Acetyl-Coa Carboxylase
Hormone-Sensitive Lipase
Human Skeletal-Muscle
Coenzyme-A Carboxylase
Acid-Binding Protein
Chronic Leptin Treatment
Diet-Induced Obesity
Malonyl-Coa
Glycerol-3-Phosphate Acyltransferase
3-Hydroxy-3-Methylglutaryl Coenzyme
DOI - identifier 10.1139/Y06-005
Copyright notice © 2006 NRC Canada
ISSN 0008-4212
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