Arteriolar myogenic signalling mechanisms: Implications for local vascular function

Hill, M, Davis, M, Meininger, G, Potocnik, S and Murphy, T 2006, 'Arteriolar myogenic signalling mechanisms: Implications for local vascular function', Clinical Hemorheology And Microcirculation, vol. 34, pp. 67-79.


Document type: Journal Article
Collection: Journal Articles

Title Arteriolar myogenic signalling mechanisms: Implications for local vascular function
Author(s) Hill, M
Davis, M
Meininger, G
Potocnik, S
Murphy, T
Year 2006
Journal name Clinical Hemorheology And Microcirculation
Volume number 34
Start page 67
End page 79
Total pages 13
Publisher IOS Press
Abstract Arterioles typically exist in a state of partial constriction that is related to the level of intraluminal pressure. This vasomotor response is a function of the vascular smooth muscle and occurs independently of neurohumoral and endothelial input. The physiological relevance of myogenic constriction relates to the setting of peripheral resistance, provision of a level of tone that vasodilators can access, and a contribution to control of capillary pressure. Despite its importance in the regulation of microvascular haemodynamics the exact cellular mechanisms linking intraluminal pressure to myogenic constriction remain uncertain. Studies using isolated, cannulated arteriole techniques, and freshly dispersed smooth muscle cells, have shown that increased intraluminal pressure/cell stretch leads to smooth muscle cell membrane depolarisation, the opening of L-type voltage-gated Ca2+ channels (VGCC), Ca2+-dependent activation of myosin light chain kinase and actomyosin-based contraction. Questions remain as to how the initial stimulus is detected and how these events lead to membrane depolarisation. A candidate pathway for the mechanosensory events involves the link between extracellular matrix proteins, cell surface integrins and the subsequent activation of intracellular signalling events.
Subject Pharmaceutical Sciences
Keyword(s) Hermatology
Peripheral Vascular Disease
ISSN 1386-0291
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