Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites

Lee, J, Pinnamaneni, S, Eo, S, Cho, I, Pyo, J, Kim, C, Sinclair, A, Febbraio, M and Watt, M 2006, 'Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites', Journal of Applied Physiology, vol. 100, pp. 1467-1474.


Document type: Journal Article
Collection: Journal Articles

Title Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites
Author(s) Lee, J
Pinnamaneni, S
Eo, S
Cho, I
Pyo, J
Kim, C
Sinclair, A
Febbraio, M
Watt, M
Year 2006
Journal name Journal of Applied Physiology
Volume number 100
Start page 1467
End page 1474
Total pages 8
Publisher American Physiological Society
Abstract Consumption of a Western diet rich in saturated fats is associated with obesity and insulin resistance. In some insulin-resistant phenotypes this is associated with accumulation of skeletal muscle fatty acids. We examined the effects of diets high in saturated fatty acids (Sat) or n-6 polyunsaturated fatty acids (PUFA) on skeletal muscle fatty acid metabolite accumulation and whole-body insulin sensitivity. Male Sprague-Dawley rats were fed a chow diet (16% calories from fat, Con) or a diet high (53%) in Sat or PUFA for 8 wk. Insulin sensitivity was assessed by fasting plasma glucose and insulin and glucose tolerance via an oral glucose tolerance test. Muscle ceramide and diacylglycerol (DAG) levels and triacylglycerol (TAG) fatty acids were also measured. Both high-fat diets increased plasma free fatty acid levels by 30%. Compared with Con, Sat-fed rats were insulin resistant, whereas PUFA-treated rats showed improved insulin sensitivity. Sat caused a 125% increase in muscle DAG and a small increase in TAG. Although PUFA also resulted in a small increase in DAG, the excess fatty acids were primarily directed toward TAG storage (105% above Con).
Subject Nutrition and Dietetics not elsewhere classified
Keyword(s) Protein-Kinase-C
Diacylglycerol Acyltransferase Activity
Sphingomyelin-Signaling Pathway
Stearoyl-Coa Desaturase-1
Skeletal-Muscle Cells
Dietary-Fat
Triacylglycerol Synthesis
Receptor Substrate-1
Glycogen-Synthesis
Sensitivity
DOI - identifier 10.1152/japplphysiol.01438.2005
ISSN 8750-7587
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