Muscle-derived interleukin-6: Lipolytic, anti-inflammatory and immune regulatory effects

Pedersen, B, Steensberg, A, Keller, P, Keller, C, Fischer, C, Hiscock, N, van Hall, G, Plomgaard, P and Febbraio, M 2003, 'Muscle-derived interleukin-6: Lipolytic, anti-inflammatory and immune regulatory effects', Pfluegers Archiv, vol. 446, no. 1, pp. 9-16.


Document type: Journal Article
Collection: Journal Articles

Title Muscle-derived interleukin-6: Lipolytic, anti-inflammatory and immune regulatory effects
Author(s) Pedersen, B
Steensberg, A
Keller, P
Keller, C
Fischer, C
Hiscock, N
van Hall, G
Plomgaard, P
Febbraio, M
Year 2003
Journal name Pfluegers Archiv
Volume number 446
Issue number 1
Start page 9
End page 16
Total pages 8
Publisher Springer-Verlag
Abstract Interleukin-6 (IL-6) is produced locally in working skeletal muscle and can account for the exercise-induced increase in plasma IL-6. The transcription rate for IL-6 in muscle nuclei isolated from muscle biopsies during exercise is very high and is enhanced further when muscle glycogen content is low. Furthermore, cultured human primary muscle cells can increase IL-6 mRNA when incubated with the calcium ionophore ionomycin and it is likely that myocytes produce IL-6 in response to muscle contraction. The biological roles of muscle-derived IL-6 have been investigated in studies in which human recombinant IL-6 was infused in healthy volunteers to mimic closely the IL-6 concentrations observed during prolonged exercise. Using stable isotopes, we have demonstrated that physiological concentrations of IL-6 induce lipolysis. Although we have yet to determine the precise biological action of muscle-derived IL-6, our data support the hypothesis that the role of IL-6 released from contracting muscle during exercise is to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery during exercise. In addition, IL-6 inhibits low-level TNF-alpha production, and IL-6 produced during exercise probably inhibits TNF-alpha-induced insulin resistance in peripheral tissues. Hence, IL-6 produced by skeletal muscle during contraction may play an important role in the beneficial health effects of exercise.
Subject Cell Physiology
Keyword(s) Cytokine
Interleukin
Muscle
Metabolism
Exercise
Physical activity
DOI - identifier 10.1007/s00424-002-0981-z
Copyright notice © Springer-Verlag 2003
ISSN 0031-6768
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