Hepatosplanchnic clearance of interleukin-6 in humans during exercise

Febbraio, M, Ott, P, Nielsen, H, Steensberg, A, Keller, C, Krustrup, P, Secher, N and Pedersen, B 2003, 'Hepatosplanchnic clearance of interleukin-6 in humans during exercise', American Journal of Physiology: Endocrinology and Metabolism, vol. 285, pp. 397-402.


Document type: Journal Article
Collection: Journal Articles

Title Hepatosplanchnic clearance of interleukin-6 in humans during exercise
Author(s) Febbraio, M
Ott, P
Nielsen, H
Steensberg, A
Keller, C
Krustrup, P
Secher, N
Pedersen, B
Year 2003
Journal name American Journal of Physiology: Endocrinology and Metabolism
Volume number 285
Start page 397
End page 402
Total pages 6
Publisher American Physiological Society
Abstract The cytokine interleukin (IL)-6 can increase markedly in the circulation during exercise, but whether the liver is a source of this increase is unknown. The aim of this study was to measure IL-6 flux across the hepatosplanchnic tissues in humans. To elevate systemic concentrations of IL-6, six healthy male subjects performed 120 min of semirecumbent cycling, and blood samples were simultaneously obtained from a brachial artery and the hepatic vein before and during exercise for the analysis of IL-6. Hepatosplanchnic blood flow (HBF) was measured using the indocyanine green infusion technique. Net hepatosplanchnic IL-6 balance was calculated from these measures. HBF was 1.3 ± 0.1 l/min at rest and was not reduced throughout exercise, averaging 1.1 ± 0.2 1/min. Arterial plasma IL-6 markedly increased (P < 0.05) from 1.8 ± 0.6 ng/l at rest to 14.3 ± 3.2 ng/l after 120 min of exercise. The hepatosplanchnic viscera did not contribute to this increase, since there was a net hepatosplanchnic IL-6 uptake (0.8 ± 0.3 vs. 5.6 ± 1.9 ng/min, rest vs. 120 min; P < 0.05). These data demonstrate that the hepatosplanchnic viscera remove IL-6 from the circulation in humans. This removal may constitute a mechanism limiting the negative chronic metabolic action of chronically elevated circulating IL-6.
Subject Exercise Physiology
Keyword(s) Blood flow
Cytokine
Liver
Metabolism
Skeletal muscle contraction
DOI - identifier 10.1152/ajpendo.00134.2003
Copyright notice © 2003 American Physiological Society
ISSN 0193-1849
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