Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans

Starkie, R, Ostrowski, S, Jauffred, S, Febbraio, M and Pedersen, B 2003, 'Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans', The FASEBJ Journal, vol. 17, no. 8, pp. 884-886.


Document type: Journal Article
Collection: Journal Articles

Title Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans
Author(s) Starkie, R
Ostrowski, S
Jauffred, S
Febbraio, M
Pedersen, B
Year 2003
Journal name The FASEBJ Journal
Volume number 17
Issue number 8
Start page 884
End page 886
Total pages 3
Publisher Federation of American Societies for Experimental Biology
Abstract During "nondamaging" exercise, skeletal muscle markedly releases interleukin (IL)-6, and it has been suggested that one biological role of this phenomenon is to inhibit the production of tumor necrosis factor (TNF)- alpha, which is known to cause pathogenesis such as insulin resistance and atherosclerosis. To test this hypothesis, we performed three experiments in which eight healthy males either rested (CON), rode a bicycle for 3 h (EX), or were infused with recombinant human IL-6 (rhIL-6) for 3 h while they rested. After 2.5 h, the volunteers received a bolus of Escherichia coli lipopolysaccharide endotoxin (0.06 ng/kg) i.v. to induce low-grade inflammation. In CON, plasma TNF-alpha increased significantly in response to endotoxin. In contrast, during EX, which resulted in elevated IL-6, and rhIL-6, the endotoxin-induced increase in TNF-alpha was totally attenuated. In conclusion, physical exercise and rhIL-6 infusion at physiological concentrations inhibit endotoxin-induced TNF-alpha production in humans. Hence, these data provide the first experimental evidence that physical activity mediates antiinflammatory activity and suggest that the mechanism include IL-6, which is produced by and released from exercising muscles.
Subject Exercise Physiology
Keyword(s) cytokines
interleukins
inflammation
physical activity
DOI - identifier 10.1096/fj.02-0670fje
Copyright notice © 2003 FASEB
ISSN 0892-6638
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