A bioactive diterpene from Smallanthus sonchifolius
Ragusa, C, Alimboyoguen, A, Urban, S and Raga, D 2008, 'A bioactive diterpene from Smallanthus sonchifolius', Natural Product Communications, vol. 3, no. 10, pp. 1663-1666.
The dichloromethane extract of the air-dried leaves and freeze-dried tubers of Smallanthus sonchifolius afforded ent-kaurenoic acid (1). The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy and was found to exhibit significant analgesic and anti-inflammatory activities. Ent-kaurenoic acid (1), dissolved in dimethylsulfoxide, also displayed potential anti-diabetes and anti-toxicity activity. In addition, 1 showed low antimicrobial activities against E. coli, P. aeruginosa, S. aureus, C. albicans and T. mentagrophytes, but was found to be inactive against B. subtilis and A. niger.
