A bioactive diterpene from Smallanthus sonchifolius

Ragusa, C, Alimboyoguen, A, Urban, S and Raga, D 2008, 'A bioactive diterpene from Smallanthus sonchifolius', Natural Product Communications, vol. 3, no. 10, pp. 1663-1666.


Document type: Journal Article
Collection: Journal Articles

Title A bioactive diterpene from Smallanthus sonchifolius
Author(s) Ragusa, C
Alimboyoguen, A
Urban, S
Raga, D
Year 2008
Journal name Natural Product Communications
Volume number 3
Issue number 10
Start page 1663
End page 1666
Total pages 4
Publisher Natural Product Inc
Abstract The dichloromethane extract of the air-dried leaves and freeze-dried tubers of Smallanthus sonchifolius afforded ent-kaurenoic acid (1). The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy and was found to exhibit significant analgesic and anti-inflammatory activities. Ent-kaurenoic acid (1), dissolved in dimethylsulfoxide, also displayed potential anti-diabetes and anti-toxicity activity. In addition, 1 showed low antimicrobial activities against E. coli, P. aeruginosa, S. aureus, C. albicans and T. mentagrophytes, but was found to be inactive against B. subtilis and A. niger.
Subject Natural Products Chemistry
Biologically Active Molecules
Keyword(s) Smallanthuis sonchifolius
yacon
Asteraceae
ent-kaurenoic acid
anti-inflammatory
analgesic
ISSN 1934-578X
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Created: Fri, 21 Jan 2011, 07:28:00 EST by Catalyst Administrator
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