Novel therapeutic targets for axonal degeneration in multiple sclerosis

Petratos, S, Azari, M, Ozturk, E, Papadopoulos, R and Bernard, C 2010, 'Novel therapeutic targets for axonal degeneration in multiple sclerosis', Journal of Neuropathology and Experimental Neurology, vol. 69, no. 4, pp. 323-334.


Document type: Journal Article
Collection: Journal Articles

Title Novel therapeutic targets for axonal degeneration in multiple sclerosis
Author(s) Petratos, S
Azari, M
Ozturk, E
Papadopoulos, R
Bernard, C
Year 2010
Journal name Journal of Neuropathology and Experimental Neurology
Volume number 69
Issue number 4
Start page 323
End page 334
Total pages 12
Publisher Wolters Kluwer/Lippincott Williams and Wilkins
Abstract Multiple sclerosis (MS) is a devastating neurological condition that mainly affects young adults and is associated with long-standing morbidity. The pathophysiology of MS is believed to involve immune-mediated multi focal lesions in the CNS that are characterized by inflammation. demyelination. and axonal injury. Most research efforts to date have concentrated on the mechanisms of immune-mediated demyelination. whereas mechanisms of axonal injury. the major detenninant of neurological deficits in MS patients. have been elusive beyond observational analyses. This review discusses current understanding of the pathology and novel clinical investigations of axonal injury in MS and the commonly used MS animal model. experimental autoimmune encephalomyelitis. The review focuses on the etiology and the induction of axonal degeneration through molecular signaling cascades downstream of myelinassociated inhibitory factors. Defining and eventually elucidating the signaling pathways elicited during the onset and progression of MS may provide novel therapeutic strategies to limit axonal degeneration in the acute phase of the disease. Furthermore. blocking or potentiating specific signaling pathways. particularly those that mediate axon retraction and promote disassembly of the tubulin network, may promote regrowth of damaged axons in CNS regions affected by many acute and chronic disease processes.
Subject Neurology and Neuromuscular Diseases
Keyword(s) Axonal degeneration. CRMP-2
Experimental autoimmune encephalomyelitis
Multiple sclerosis
Myelin-associated inhibitory factors. Nogo-A
RhoA.
DOI - identifier 10.1097/NEN.0b013e3181d60ddb
Copyright notice © 2010 by Ihe American Association of Neuropathologists, Inc.
ISSN 0022-3069
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