The electromagnetic field as a modulator of a protein activity, and the resonant recognition model

Vojisavljevic, V 2007, The electromagnetic field as a modulator of a protein activity, and the resonant recognition model, Doctor of Philosophy (PhD), Electrical and Computer Engineering, RMIT University.


Document type: Thesis
Collection: Theses

Attached Files
Name Description MIMEType Size
Vojisavljevic.pdf Thesis application/pdf 2.15MB
Title The electromagnetic field as a modulator of a protein activity, and the resonant recognition model
Author(s) Vojisavljevic, V
Year 2007
Abstract In this study, it was experimentally proved, for the first time, that it is possible to predict the frequency of electromagnetic radiation that can modulate activity of proteins and more specifically activity of enzymes. The prediction was obtained using the computational model so called the Resonant Recognition Model (RRM). The model was tested here experimentally using the reaction catalysed with the enzyme l-lactate dehydrogenase (LDH). The RRM model was applied to the group of the enzymes belonging to the sub-subclass EC 1.1.1.27 i.e. l-lactate dehydrogenase. The wavelengths of the electro magnetic radiation calculated by the RRM and proposed to alternate activity of l-lactate dehydrogenate were identified at =620 25 nm and =840 25 nm. Enzyme activity was then measured after the exposure to the low-intensity, electromagnetic radiation (EMR) within the proposed EMR range [560-860 nm]. The experimental results have indeed shown that there is a significant increase in the activity of LDH only after irradiation within the range of the frequencies predicted by the RRM: 596nm (12%; P less than 0.001) and 829 nm (11.8%, P less than 0.001). These results prove successfully that activity of proteins and more specifically enzymes could be modified by EMR radiation of specific frequencies and even more that RRM computational model can successfully predict these frequencies.
Degree Doctor of Philosophy (PhD)
Institution RMIT University
School, Department or Centre Electrical and Computer Engineering
Keyword(s) Enzymes
Electromagnetic radiation
Versions
Version Filter Type
Access Statistics: 266 Abstract Views, 1072 File Downloads  -  Detailed Statistics
Created: Wed, 16 Feb 2011, 14:04:07 EST
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us