Micron particle deposition in a tracheobronchial airway model under different breathing conditions

Inthavong, K, Choi, L, Tu, J, Ding, S and Thien, F 2010, 'Micron particle deposition in a tracheobronchial airway model under different breathing conditions', Medical Engineering & Physics, vol. 32, no. 10, pp. 1198-1212.


Document type: Journal Article
Collection: Journal Articles

Title Micron particle deposition in a tracheobronchial airway model under different breathing conditions
Author(s) Inthavong, K
Choi, L
Tu, J
Ding, S
Thien, F
Year 2010
Journal name Medical Engineering & Physics
Volume number 32
Issue number 10
Start page 1198
End page 1212
Total pages 15
Publisher Elsevier Sci Ltd
Abstract Effective management of asthma is dependent on achieving adequate delivery of the drugs into the lung. Inhalers come in the form of dry powder inhalers (DPIs) and metered dose inhalers (pMDIs) with the former requiring a deep fast breath for activation while there are no restrictions on inhalation rates for the latter. This study investigates two aerosol medication delivery methods (i) an idealised case for drug particle delivery under a normal breathing cycle (inhalation-exhalation) and (ii) for an increased effort during the inhalation with a breath hold. A computational model of a human tracheobronchial airway was reconstructed from computerised tomography (CT) scans. The model's geometry and lobar flow distribution were compared with experimental and empirical models to verify the current model. Velocity contours and secondary flow vectors showed vortex formation downstream of the bifurcations which enhanced particle deposition. The velocity contour profiles served as a predictive tool for the final deposition patterns. Different spherical aerosol particle sizes (3-10µm, 1.55g/cm(3)) were introduced into the airway for comparison over a range of Stokes number. It was found that a deep inhalation with a breath hold of 2s did not necessarily increase later deposition up to the sixth branch generation, but rather there was an increase in the deposition in the first few airway generations was found. In addition the breath hold allows deposition by sedimentation which assists in locally targeted deposition. Visualisation of particle deposition showed local "hot-spots" where particle deposition was concentrated in the lung airway.
Subject Biomechanical Engineering
Keyword(s) Dry Powder Inhalers
Human Nasal Airway
Inspiratory Flow
Double-Bifurcation
Velocity Profiles
Laryngeal Jet
Transport
Lung
Delivery
Asthma
DOI - identifier 10.1016/j.medengphy.2010.08.012
Copyright notice © 2010 IPEM. Published by Elsevier Ltd. All rights reserved.
ISSN 1350-4533
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