An updated unified pharmacophore model of the benzodiazepine binding site on Y-aminobutyric acidA receptors: correlation with comparative models

Clayton, T, Chen, J, Ernst, M, Richter, L, Cromer, B, Morton, C, Ng, H, Kaczorowski, C, Helmstetter, F, Furtmuller, R, Ecker, G, Parker, M, Sieghart, W and Cook, J 2007, 'An updated unified pharmacophore model of the benzodiazepine binding site on Y-aminobutyric acidA receptors: correlation with comparative models', Current Medicinal Chemistry, vol. 14, no. 26, pp. 2755-2775.


Document type: Journal Article
Collection: Journal Articles

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Title An updated unified pharmacophore model of the benzodiazepine binding site on Y-aminobutyric acidA receptors: correlation with comparative models
Author(s) Clayton, T
Chen, J
Ernst, M
Richter, L
Cromer, B
Morton, C
Ng, H
Kaczorowski, C
Helmstetter, F
Furtmuller, R
Ecker, G
Parker, M
Sieghart, W
Cook, J
Year 2007
Journal name Current Medicinal Chemistry
Volume number 14
Issue number 26
Start page 2755
End page 2775
Total pages 21
Publisher Bentham Science Publishers Ltd.
Abstract A successful unified pharmacophore/receptor model which has guided the synthesis of subtype selective compounds is reviewed in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of experimental data in combination with a comparative model of the alpha1beta2gamma2 GABA(A) receptor leads to an orientation of the pharmacophore model within the Bz BS. Results not only are important for the rational design of selective ligands, but also for the identification and evaluation of possible roles which specific residues may have within the benzodiazepine binding pocket.
Subject Basic Pharmacology
Keyword(s) Aminobutyric acid(A) receptors
gated ion channels
GABA-A
computer-assisted analysis
benzodiazepine
Copyright notice Copyright © 2007 Bentham Science Publishers Ltd.
ISSN 0929-8673
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