Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway

Tan, M, Ye, J, Turner, N, Hohnen-Behrens, C, Ke, C, Tang, C, Chen, T, Weiss, H, Gesing, E, Rowland, A, James, D and Yang, Y 2008, 'Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway', Chemistry and Biology, vol. 15, no. 3, pp. 263-273.


Document type: Journal Article
Collection: Journal Articles

Title Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway
Author(s) Tan, M
Ye, J
Turner, N
Hohnen-Behrens, C
Ke, C
Tang, C
Chen, T
Weiss, H
Gesing, E
Rowland, A
James, D
Yang, Y
Year 2008
Journal name Chemistry and Biology
Volume number 15
Issue number 3
Start page 263
End page 273
Total pages 11
Publisher Cell Press
Abstract Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-established karaviloside XI, were isolated from the vegetable bitter melon (Momordica charantia). These compounds and their aglycones exhibited a number of biologic effects beneficial to diabetes and obesity. In both L6 myotubes and 3T3-L1 adipocytes, they stimulated GLUT4 translocation to the cell membrane-an essential step for inducible glucose entry into cells. This was associated with increased activity of AMP-activated protein kinase (AMPK), a key pathway mediating glucose uptake and fatty acid oxidation. Furthermore, momordicoside(s) enhanced fatty acid oxidation and glucose disposal during glucose tolerance tests in both insulin-sensitive and insulin-resistant mice. These findings indicate that cucurbitane triterpenoids, the characteristic constituents of M. charantia, may provide leads as a class of therapeutics for diabetes and obesity.
Subject Medicinal and Biomolecular Chemistry not elsewhere classified
Keyword(s) CHEMBIO
SIGNALING
DOI - identifier 10.1016/j.chembiol.2008.01.013
Copyright notice © 2008 Elsevier Ltd. All rights reserved
ISSN 1074-5521
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 236 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 218 times in Scopus Article | Citations
Altmetric details:
Access Statistics: 312 Abstract Views  -  Detailed Statistics
Created: Fri, 28 Oct 2011, 11:11:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us