Development of a haemodynamic model for improving clinical treatment of vascular disease

Dong, J 2015, Development of a haemodynamic model for improving clinical treatment of vascular disease, Doctor of Philosophy (PhD), Aerospace, Mechanical and Manufacturing Engineering, RMIT University.

Document type: Thesis
Collection: Theses

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Title Development of a haemodynamic model for improving clinical treatment of vascular disease
Author(s) Dong, J
Year 2015
Abstract Atherosclerosis is a chronic artery disease that leads to heart attack and stroke; affecting millions of people worldwide. It tends to develop in locations where disturbed flow patterns occur, such as the carotid artery, left coronary artery and abdominal aorta. The causative factors leading to atherosclerosis still remain relatively poorly understood. Conventional diagnosis of arterial disease relies on a combination of history, clinical examination and clinical imaging derived from CT, MRI, etc. To address some of the important factors related to arterial haemodynamics, Computational Fluid Dynamics (CFD) studies were performed on in-vitro models using physiologically relevant conditions. The flow disturbances in terms of wall shear stress and oscillatory shear index were examined. Based on the current research, new insights from a haemodynamics point of view were provided. This study aims to enrich and complement the current arterial disease research, and contribute to promoting the diagnosis accuracy and efficiency in the future.

This thesis is composed by six parts of work. Firstly, a comprehensive literature review was performed to identify the research gaps between the current relevant numerical studies with real clinical application. Secondly, the proposed CFD model was validated with published experimental work using particle image velocimetry (PIV) approach. A downstream impedance model was then developed to improve numerical simulation accuracy for image-based artery bifurcations. The numerical results were correlated with a clinical indicator to provide relevant findings for treating physicians. Lastly, a fully fluid-structure interaction (FSI) modelling over left coronary artery models with different bifurcation angles was conducted. The relationship between the mechanical force (first principle stress), the hemodynamic force (wall shear stress), and the bifurcation angle was analysed.

In summary, this thesis developed a new downstream artery impedance model, and converted the numerical simulation results into clinical indicators, which can improve the current simulation accuracy and contribute more meaningful results to assist a better clinical diagnosis. A FSI simulation was performed over left coronary artery bifurcation models. The bifurcation angle influence on atherosclerosis progression was addressed. The left circumflex side bifurcation shoulder was found to be more vulnerable in developing atherosclerosis.
Degree Doctor of Philosophy (PhD)
Institution RMIT University
School, Department or Centre Aerospace, Mechanical and Manufacturing Engineering
Keyword(s) Atherosclerosis
Artery bifurcation
Computational fluid dynamics
Particle image velocimetry
Fluid-structure interaction
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Created: Tue, 08 Sep 2015, 13:44:34 EST by Denise Paciocco
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