Anxiety and hypothalamic-pituitary-adrenal axis responses to psychological stress are attenuated in male rats made lean by large litter rearing

Bulfin, L, Clarke, M, Buller, K and Spencer, S 2011, 'Anxiety and hypothalamic-pituitary-adrenal axis responses to psychological stress are attenuated in male rats made lean by large litter rearing', Psychoneuroendocrinology, vol. 36, no. 7, pp. 1080-1091.


Document type: Journal Article
Collection: Journal Articles

Title Anxiety and hypothalamic-pituitary-adrenal axis responses to psychological stress are attenuated in male rats made lean by large litter rearing
Author(s) Bulfin, L
Clarke, M
Buller, K
Spencer, S
Year 2011
Journal name Psychoneuroendocrinology
Volume number 36
Issue number 7
Start page 1080
End page 1091
Total pages 12
Publisher Pergamon
Abstract An excellent strategy to treat overactive responses to stress is to exploit the body's inherent stress-inhibitory mechanisms. Stress responses are known to differ between individuals depending upon their level and distribution of adiposity and their experiences in early life. For instance, we have recently shown that female rats made obese by overfeeding during the neonatal period have exacerbated responses to psychological stress. The converse may be true for those that are underfed during this period. In this investigation we hypothesized that rats made lean by neonatal underfeeding would have reduced anxiety and attenuated hypothalamic-pituitary-adrenal (HPA) axis responses to psychological stress. Our findings show that male (but not female) rats, made smaller by being suckled in a large litter, show reduced anxiety-related behaviour compared with those from normal litters when tested in the elevated plus maze
Subject Endocrinology
Keyword(s) Development
HPA
Lean
Nutrition
Obesity
Stress
DOI - identifier 10.1016/j.psyneuen.2011.01.006
Copyright notice © 2011 Elsevier Ltd
ISSN 0306-4530
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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