An omics based assessment of cadmium toxicity in the green alga Chlamydomonas reinhardtii

Jamers, A, Blust, R, Coen, W, Griffin, J and Jones, O 2013, 'An omics based assessment of cadmium toxicity in the green alga Chlamydomonas reinhardtii', Aquatic Toxicology, vol. 126, no. 1, pp. 355-364.


Document type: Journal Article
Collection: Journal Articles

Title An omics based assessment of cadmium toxicity in the green alga Chlamydomonas reinhardtii
Author(s) Jamers, A
Blust, R
Coen, W
Griffin, J
Jones, O
Year 2013
Journal name Aquatic Toxicology
Volume number 126
Issue number 1
Start page 355
End page 364
Total pages 10
Publisher Elsevier BV
Abstract The effects of cadmium were assessed in the freshwater alga Chlamydomonas reinhardtii. Algae were exposed to concentrations of 0, 8.1 or 114.8 μM of cadmium and growth rates, gene transcription and metabolite profiles were examined after 48 and 72 h of exposure. In algae exposed to 8.1 μM Cd, several genes were differentially transcribed after 48 h but no adverse growth related effects were detected. A transient effect on both gene transcription patterns and metabolite profiles could be discerned after 48 h of exposure but the majority of these changes disappeared after 72 h. In contrast, all effects were more pronounced at the 114.8 μM cadmium exposure. Here growth was clearly reduced and transcription of a large number of genes involved in oxidative stress defense mechanisms was differentially increased. Metabolites involved in the glutathione synthesis pathway (an important antioxidant defense) were also affected but the effects of cadmium were found to be more pronounced at the transcript level than in the metabolome, suggesting that the former exhibits greater sensitivity toward cadmium exposure.
Subject Biochemistry and Cell Biology not elsewhere classified
Keyword(s) Cadmium
Metabonomics
Oxidative stress
Systems toxicology
DOI - identifier 10.1016/j.aquatox.2012.09.007
Copyright notice © 2012 Elsevier B.V. All rights reserved.
ISSN 0166-445X
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