Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (aphyllophoromycetideae): A review

Gao, Y, Zhou, S, Huang, M and Xu, A 2003, 'Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (aphyllophoromycetideae): A review', International Journal of Medicinal Mushrooms, vol. 5, no. 3, pp. 235-246.


Document type: Journal Article
Collection: Journal Articles

Title Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (aphyllophoromycetideae): A review
Author(s) Gao, Y
Zhou, S
Huang, M
Xu, A
Year 2003
Journal name International Journal of Medicinal Mushrooms
Volume number 5
Issue number 3
Start page 235
End page 246
Total pages 12
Publisher Begell House Inc
Abstract Various effective synthetic antibacterial and antiviral agents have been developed, but drug resistance and toxicity may occur. Herbal medicines may represent a safe and useful approach for the treatment of infectious diseases. Ganoderma lucidum and other Ganoderma species, alone or more often in combination with chemotherapeutic agents, have been used to treat chronic infectious diseases such as chronic hepatitis and bronchitis, although there is limited clinical data available. Data from in vitro and in vivo animal studies indicate that G. lucidum and other Ganoderma species exhibit a broad spectrum of antibacterial and antiviral activities. A recent randomized placebo-controlled clinical study indicates that treatment with G. lucidum polysaccharides at 5400 mg/day for 12 weeks caused inhibitory effects on hepatitis B virus (HBV) replication, as indicated by the decreased serum HBV DNA and hepatitis B e antigen (HBeAg) levels. It appears that both polysaccharides and triterpenoids are the major antiviral constituents of Ganoderma species, while the polysaccharides play a more important role for its antibacterial activity. There appears to be a structure-activity relationship for triterpenoid-mediated antiviral effect. The mechanisms for the antibacterial and antiviral activities of G. lucidum and other Ganoderma species are largely undefined. Ganoderma constituents (e.g., polysaccharides and triterpenoids) may inhibit viral replication by interfering with their adsorption, virus-hepatocyte fusion and endocytosis, and viral integration, assembly, and release. Currently available data suggest that G. lucidum and some other Ganoderma species may play an adjunct role for the management of various infectious diseases, and further experimental and clinical studies are needed.
Subject Complementary and Alternative Medicine not elsewhere classified
DOI - identifier 10.1615/InterJMedicMush.v5.i3.20
Copyright notice © 2003 Begell House Inc
ISSN 1521-9437
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