Application of HPLC-NMR in the identification of plocamenone and isoplocamenone from the marine red alga Plocamium angustum

Timmers, M, Dias, D and Urban, S 2012, 'Application of HPLC-NMR in the identification of plocamenone and isoplocamenone from the marine red alga Plocamium angustum', Marine Drugs, vol. 10, no. 9, pp. 2089-2102.


Document type: Journal Article
Collection: Journal Articles

Title Application of HPLC-NMR in the identification of plocamenone and isoplocamenone from the marine red alga Plocamium angustum
Author(s) Timmers, M
Dias, D
Urban, S
Year 2012
Journal name Marine Drugs
Volume number 10
Issue number 9
Start page 2089
End page 2102
Total pages 14
Publisher M D P I AG
Abstract A combination of on-line HPLC-NMR and off-line chemical investigations has resulted in the identification of the previously reported polyhalogenated monoterpene plocamenone, together with the new structural analogue isoplocamenone from the crude extract of the marine alga Plocamium angustum. On-flow and stop-flow HPLC-NMR analyses (including the acquisition of WET 2D NMR spectra) rapidly assisted in the identification of the major component plocamenone and in the partial identification of its unstable double bond isomer isoplocamenone. Conventional off-line isolation and structural characterization techniques were employed to unequivocally confirm both structures, leading to a structural revision for plocamenone, as well as to obtain sufficient quantities for biological testing.
Subject Natural Products Chemistry
Keyword(s) Biological activity
HPLC-NMR
Hyphenated spectroscopy
Plocamium angustum
Polyhalogenated acyclic monoterpenes
DOI - identifier 10.3390/md10092089
Copyright notice © 2012 by the authors; licensee MDPI.
ISSN 1660-3397
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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