A historical overview of natural products in drug discovery

Dias, D, Urban, S and Roessner, U 2012, 'A historical overview of natural products in drug discovery', Metabolites, vol. 2, no. 2, pp. 303-336.

Document type: Journal Article
Collection: Journal Articles

Title A historical overview of natural products in drug discovery
Author(s) Dias, D
Urban, S
Roessner, U
Year 2012
Journal name Metabolites
Volume number 2
Issue number 2
Start page 303
End page 336
Total pages 34
Publisher M D P I AG
Abstract Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed
Subject Natural Products Chemistry
Chemical Sciences not elsewhere classified
Separation Science
Keyword(s) Natural products
secondary metabolites
drug discovery
DOI - identifier 10.3390/metabo2020303
Copyright notice © 2012 M D P I AG
ISSN 2218-1989
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