Cardiovascular actions and therapeutic potential of tanshinone IIA

Gao, S, Liu, Z, Li, H, Little AM, P, Liu, P and Xu, S 2012, 'Cardiovascular actions and therapeutic potential of tanshinone IIA', Atherosclerosis, vol. 220, no. 2, pp. 3-10.


Document type: Journal Article
Collection: Journal Articles

Title Cardiovascular actions and therapeutic potential of tanshinone IIA
Author(s) Gao, S
Liu, Z
Li, H
Little AM, P
Liu, P
Xu, S
Year 2012
Journal name Atherosclerosis
Volume number 220
Issue number 2
Start page 3
End page 10
Total pages 8
Publisher Elsevier
Abstract Tanshinone IIA (TS), a pharmacologically active component isolated from the rhizome of the Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been clinically used in Asian countries for the prevention and treatment of coronary heart disease. Recently, the pharmacological properties of TS in the cardiovascular system have attracted great interest. Emerging experimental studies and clinical trials have demonstrated that TS prevents atherogenesis as well as cardiac injury and hypertrophy. In atherosclerosis, TS acts by inhibiting LDL oxidation, monocyte adhesion to endothelium, smooth muscle cell migration and proliferation, macrophage cholesterol accumulation, proinflammatory cytokine expression and platelet aggregation. TS has some activity and potential to stabilize atherosclerotic plaques. The cardioprotective effects of TS are mainly related to its anti-oxidant and anti-inflammatory actions. In this review, we focus on the protective effects and the mechanism of action of TS in the cardiovascular system, and provide a novel perspective on clinical use of TS.
Subject Pharmaceutical Sciences
Keyword(s) Anti-oxidant; Atherosclerosis; Cardiac hypertrophy; Myocardial infarction; Oxidized LDL; Tanshinone IIA
DOI - identifier 10.1016/j.atherosclerosis.2011.06.041
Copyright notice © 2011 Elsevier Ireland Ltd.
ISSN 0021-9150
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