Are nicotinic acetylcholine receptors coupled to G proteins?

Kabbani, N, Nordman, J, Corgiat, B, Veltri, D, Shehu, A, Seymour, V and Adams, D 2013, 'Are nicotinic acetylcholine receptors coupled to G proteins?', BioEssays, vol. 35, no. 12, pp. 1025-1034.


Document type: Journal Article
Collection: Journal Articles

Title Are nicotinic acetylcholine receptors coupled to G proteins?
Author(s) Kabbani, N
Nordman, J
Corgiat, B
Veltri, D
Shehu, A
Seymour, V
Adams, D
Year 2013
Journal name BioEssays
Volume number 35
Issue number 12
Start page 1025
End page 1034
Total pages 10
Publisher John Wiley & Sons
Abstract It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding to G proteins modulates the activity and signaling of nAChRs in cells. It is important to note that while this hypothesis is new for the nAChR, it is consistent with known interactions between G proteins and structurally related ligand-gated ion channels. Therefore, it underscores an evolutionarily conserved metabotropic mechanism of G protein signaling via nAChR channels.
Subject Basic Pharmacology
Keyword(s) acetylcholine
G protein coupling
intracellular loop
ligand-gated ion channel
loop modeling
protein interaction
signal transduction
DOI - identifier 10.1002/bies.201300082
Copyright notice © 2013 WILEY Periodicals, Inc
ISSN 0265-9247
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