An investigation on platelet transport during thrombus formation at micro-scale stenosis

Tovar Lopez, F, Rosengarten, G, Nasabi, M, Sivan, V, Khoshmanesh, K, Jackson, S, Mitchell, A and Nesbitt, W 2013, 'An investigation on platelet transport during thrombus formation at micro-scale stenosis', PLoS ONE, vol. 8, no. 10, e74123, pp. 1-11.


Document type: Journal Article
Collection: Journal Articles

Title An investigation on platelet transport during thrombus formation at micro-scale stenosis
Author(s) Tovar Lopez, F
Rosengarten, G
Nasabi, M
Sivan, V
Khoshmanesh, K
Jackson, S
Mitchell, A
Nesbitt, W
Year 2013
Journal name PLoS ONE
Volume number 8
Issue number 10
Article Number e74123
Start page 1
End page 11
Total pages 11
Publisher Public Library Science
Abstract This paper reports on an investigation of mass transport of blood cells at micro-scale stenosis where local strain-rate micro-gradients trigger platelet aggregation. Using a microfluidic flow focusing platform we investigate the blood flow streams that principally contribute to platelet aggregation under shear micro-gradient conditions. We demonstrate that relatively thin surface streams located at the channel wall are the primary contributor of platelets to the developing aggregate under shear gradient conditions. Furthermore we delineate a role for red blood cell hydrodynamic lift forces in driving enhanced advection of platelets to the stenosis wall and surface of developing aggregates. We show that this novel microfluidic platform can be effectively used to study the role of mass transport phenomena driving platelet recruitment and aggregate formation and believe that this approach will lead to a greater understanding of the mechanisms underlying shear-gradient dependent discoid platelet aggregation in the context of cardiovascular diseases such as acute coronary syndromes and ischemic stroke.
Subject Renewable Power and Energy Systems Engineering (excl. Solar Cells)
DOI - identifier 10.1371/journal.pone.0074123
Copyright notice © 2013 Tovar-Lopez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ISSN 1932-6203
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