Anti-atherogenic role of Peroxisome Proliferator Activated Receptor ligands

Nigro, J, Ballinger, M, Osman, N, Dart, A and Little, P 2005, 'Anti-atherogenic role of Peroxisome Proliferator Activated Receptor ligands', Current Cardiology Reviews, vol. 1, pp. 89-102.


Document type: Journal Article
Collection: Journal Articles

Title Anti-atherogenic role of Peroxisome Proliferator Activated Receptor ligands
Author(s) Nigro, J
Ballinger, M
Osman, N
Dart, A
Little, P
Year 2005
Journal name Current Cardiology Reviews
Volume number 1
Start page 89
End page 102
Total pages 14
Publisher Bentham Science Publishers
Abstract Two families of peroxisome proliferating-activated receptor (PPAR) ligands are utilized clinically to address abnormalities of blood-borne cardiovascular risk factors. PPAR-a ligands, the fibrates, lower plasma triglycerides and increase high-density lipoprotein (HDL)-cholesterol leading to positive outcomes in clinical trials such as the Veterans Affairs HDL Intervention Trial. PPAR-? ligands, the recently introduced family of thiazolidinediones, act as insulin sensitizers to alleviate the hyperglycemia of insulin resistant states such as Type 2 diabetes. The primary aim of treating the cardiovascular risk factors is to reduce the burden of cardiovascular disease, mostly atherosclerotic vascular disease. Considerable evidence is emerging that PPAR ligands can exert anti-atherogenic activity. Although the agents acting on their target nuclear receptors are primarily regulators of gene transcription it may be that some actions are independent of gene transcription and represent direct inhibition of atherogenic signalling pathways in the vasculature. The direct actions including inhibition of vascular smooth muscle cell proliferation and inhibition of glycosaminoglycan elongation on proteoglycans, the latter leading to reduced low-density lipoprotein (LDL) binding, provide in vitro examples of antiatherogenic actions.
Keyword(s) atherosclerosis
cardiovascular disease
fibrates
glitazones
lipoprotein retention
peroxisome proliferating
activated receptor (ppar)
ISSN 1875-6557
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