Assessing the role of Gaq/11 iin cellular responses: An analysis of investigative tools

Bernard, R, Thach, L, Kamato, D, Osman, N and Little AM, P 2014, 'Assessing the role of Gaq/11 iin cellular responses: An analysis of investigative tools', Journal of Clinical and Experimental Pharmacology, vol. 4, no. 5, pp. 1-4.


Document type: Journal Article
Collection: Journal Articles

Title Assessing the role of Gaq/11 iin cellular responses: An analysis of investigative tools
Author(s) Bernard, R
Thach, L
Kamato, D
Osman, N
Little AM, P
Year 2014
Journal name Journal of Clinical and Experimental Pharmacology
Volume number 4
Issue number 5
Start page 1
End page 4
Total pages 4
Publisher OMICS Publishing Group
Abstract Seven transmembrane G Protein Coupled Receptors (GPCRs) are one of the major classes of cell surface receptors and play a major role through agonists and antagonists in human therapeutics [1]. GPCRs are associated with a group of G proteins which consist of 3 subunits termed alpha, beta and gamma. G proteins may be classified according to their effector molecules of the alpha subunit, which in mammals falls into several subtypes, Gαs, Gαi, Gα12 and Gαq. The Gαq family consists of four subunits Gαq, Gα11, Gα14 and Gα15/16. In contrast to the protein kinase receptors which have intrinsic (kinase) enzymatic activity, GPCRs do not have enzymatic activity-enzymatic activity mediating signal transduction resides in the Gα proteins which have GTPase activity [2]. Gα proteins exist in the GTP bound form. Ligand initiated conformational changes in the GPCR causes the release of bound Gα proteins. This dissociation initiates the GTPase activity, hydrolyzing GTP to GDP which is released from the proteins and allows alterative interactions leading to downstream signal transduction.
Subject Pharmaceutical Sciences
DOI - identifier 10.4172/2157-7420.1000164
Copyright notice © 2014 OMICS Publishing Group
ISSN 2161-1459
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