Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats

Chan, V, Fenning, A, Levick, S, Loch, D, Chunduri, P, Iyer, A, Teo, Y, Hoey, A, Wilson, K, Burstow, D and Brown, L 2011, 'Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats', Journal of Cardiovascular Pharmacology, vol. 57, no. 4, pp. 469-478.


Document type: Journal Article
Collection: Journal Articles

Title Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats
Author(s) Chan, V
Fenning, A
Levick, S
Loch, D
Chunduri, P
Iyer, A
Teo, Y
Hoey, A
Wilson, K
Burstow, D
Brown, L
Year 2011
Journal name Journal of Cardiovascular Pharmacology
Volume number 57
Issue number 4
Start page 469
End page 478
Total pages 10
Publisher Lippincott Williams and Wilkins
Abstract Background: Cardiovascular remodeling leading to heart failure is common in the elderly. Testing effective pharmacological treatment of human heart failure requires a suitable animal model that adequately mimics the human disease state. Methods: This study has characterized the structural, functional, and electrical characteristics of the cardiovascular system throughout the lifespan in male and female spontaneously hypertensive rats (SHRs), a genetic model of chronic hypertension-induced cardiovascular remodeling, and age-and gender-matched normotensive controls, to determine whether ageing SHRs mimic the changes seen in ageing humans. Results: Both the ageing male and female SHRs developed progressive hypertension, ventricular hypertrophy, left ventricular fibrosis, action potential prolongation without impaired glucose tolerance. Male SHRs from 15 months of age exhibited left ventricular wall thinning and chamber dilation, together with systolic and diastolic dysfunction and increased cardiac stiffness and increased erythrocyte superoxide production, which were not present in the female SHRs. Conclusion: Ageing male SHRs in contrast to the female SHRs, better mimic the chronic heart failure in humans produced by chronic hypertension. Ageing male SHRs could then be used to investigate proposed therapeutic interventions for chronic congestive heart failure in humans.
Subject Pharmacology and Pharmaceutical Sciences not elsewhere classified
Keyword(s) Ageing
gender
heart failure
hypertension
remodeling
spontaneously hypertensive rats
DOI - identifier 10.1097/FJC.0b013e3182102c3b
Copyright notice Copyright © Lippincott Williams and Wilkins. Unauthorized reproduction of this article is prohibited.
ISSN 0160-2446
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