Brain food for alzheimer-free ageing: Focus on herbal medicines

Hugel, H 2015, 'Brain food for alzheimer-free ageing: Focus on herbal medicines', Advances in Experimental Medicine and Biology, vol. 863, pp. 95-116.


Document type: Journal Article
Collection: Journal Articles

Title Brain food for alzheimer-free ageing: Focus on herbal medicines
Author(s) Hugel, H
Year 2015
Journal name Advances in Experimental Medicine and Biology
Volume number 863
Start page 95
End page 116
Total pages 22
Publisher Springer New York LLC
Abstract Healthy brain aging and the problems of dementia and Alzheimer's disease (AD) are a global concern. Beyond 60 years of age, most, if not everyone, will experience a decline in cognitive skills, memory capacity and changes in brain structure. Longevity eventually leads to an accumulation of amyloid plaques and/or tau tangles, including some vascular dementia damage. Therefore, lifestyle choices are paramount to leading either a brain-derived or a brain-deprived life. The focus of this review is to critically examine the evidence, impact, influence and mechanisms of natural products as chemopreventive agents which induce therapeutic outcomes that modulate the aggregation process of beta-amyloid (A"), providing measureable cognitive benefits in the aging process. Plants can be considered as chemical factories that manufacture huge numbers of diverse bioactive substances, many of which have the potential to provide substantial neuroprotective benefits. Medicinal herbs and health food supplements have been widely used in Asia since over 2,000 years. The phytochemicals utilized in traditional Chinese medicine have demonstrated safety profiles for human consumption. Many herbs with anti-amyloidogenic activity, including those containing polyphenolic constituents such as green tea, turmeric, Salvia miltiorrhiza, and Panax ginseng, are presented. Also covered in this review are extracts from kitchen spices including cinnamon, ginger, rosemary, sage, salvia herbs, Chinese celery and many others some of which are commonly used in herbal combinations and represent highly promising therapeutic natural compounds against AD. A number of clinical trials conducted on herbs to counter dementia and AD are discussed.
Subject Medical and Health Sciences not elsewhere classified
Keyword(s) Alzheimer's disease
Amyloid-beta
Dementia
Herbal polyphenols
Traditional Chinese medicine (TCM)
DOI - identifier 10.1007/978-3-319-18365-7_5
Copyright notice © Springer International Publishing Switzerland 2015
ISSN 0065-2598
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Altmetric details:
Access Statistics: 148 Abstract Views  -  Detailed Statistics
Created: Wed, 07 Oct 2015, 08:11:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us