Application of the resonant recognition model to the study of plasmodium proteins involved in malaria infection

Caceres, J, Cosic, I and Cosic, D 2015, 'Application of the resonant recognition model to the study of plasmodium proteins involved in malaria infection', MD Medical Data, vol. 7, no. 1, pp. 7-14.


Document type: Journal Article
Collection: Journal Articles

Title Application of the resonant recognition model to the study of plasmodium proteins involved in malaria infection
Author(s) Caceres, J
Cosic, I
Cosic, D
Year 2015
Journal name MD Medical Data
Volume number 7
Issue number 1
Start page 7
End page 14
Total pages 8
Publisher MOSTART
Abstract Invasion of the human host by plasmodium parasites involves complex interactions with key roles played by both human and plasmodium proteins. Here, using signal processing method, Resonant Recognition Model (RRM), we analyzed a group of proteins playing key roles in these invasion mechanisms. The RRM is a physico-mathematical approach analyzing protein interactions based on resonant frequency match between free electron energy distributions of interacting proteins. By identifying resonant frequencies common to several proteins involved in plasmodium infection, the main features of invasion process can be summarized. The findings of this study confirmed results from literature: interaction of band 3 protein from Red Blood Cell with both Erythrocyte Binding Antigen (EBA) and Signal Peptide Protease (SPP), following different mechanisms, common function for orthologues of Circumsporozoite protein, EBA, SPP and PfEMP. Two main characteristic frequencies were identified as relevant for parasite invasion: frequency at f=0.0020 is putatively associated to recognition of host cell membranes, whereas frequency at f=0.3400 may reflect intracellular interactions of merozoites as well as hypnozoites. The results obtained here provide a valuable insight into protein-protein interactions during plasmodium infection which could be used further to design new synthetic peptides as vaccine candidates or medications for curbing malaria.
Subject Biomedical Engineering not elsewhere classified
Keyword(s) Malaria
Circumsporozoite Protein
Erythrocyte Binding Antigen
Band 3 erythrocyte membrane
Plasmodium falciparum
Plasmodium vivax
Resonant Recognition Model
Protein-to-protein interactions
ISSN 1821-1585
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