A simplification of Cobelli's glucose-insulin model for type 1 diabetes mellitus and its FPGA implementation

Peng, L, Yu, L, Fang, J and Lee, S 2016, 'A simplification of Cobelli's glucose-insulin model for type 1 diabetes mellitus and its FPGA implementation', Medical and Biological Engineering and Computing, vol. 54, no. 10, pp. 1563-1577.


Document type: Journal Article
Collection: Journal Articles

Title A simplification of Cobelli's glucose-insulin model for type 1 diabetes mellitus and its FPGA implementation
Author(s) Peng, L
Yu, L
Fang, J
Lee, S
Year 2016
Journal name Medical and Biological Engineering and Computing
Volume number 54
Issue number 10
Start page 1563
End page 1577
Total pages 15
Publisher Springer
Abstract Cobelli's glucose-insulin model is the only computer simulator of glucose-insulin interactions accepted by Food Drug Administration as a substitute to animal trials. However, it consists of multiple differential equations that make it hard to be implemented on a hardware platform. In this investigation, the Cobelli's model is simplified by Pad, approximant method and implemented on a field-programmable gate array-based platform as a hardware model for predicting glucose changes in subjects with type 1 diabetes mellitus. Compared with the original Cobelli's model, the implemented hardware model provides a nearly perfect approximation in predicting glucose changes with rather small root-mean-square errors and maximum errors. The RMSE results for 30 subjects show that the method for simplifying and implementing Cobelli's model has good robustness and applicability. The successful hardware implementation of Cobelli's model will promote a wider adoption of this model that can substitute animal trials, provide fast and reliable glucose and insulin estimation, and ultimately assist the further development of an artificial pancreas system.
Subject Biomedical Instrumentation
Medical Devices
Keyword(s) Artificial pancreas system
FPGA
Glucose-insulin interaction model
Model order reduction
T1DM
DOI - identifier 10.1007/s11517-015-1436-y
Copyright notice © International Federation for Medical and Biological Engineering 2015
ISSN 0140-0118
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