Antibody recognition of aberrant glycosylation on the surface of cancer cells

Soliman, C, Yuriev, E and Ramsland, P 2017, 'Antibody recognition of aberrant glycosylation on the surface of cancer cells', Current Opinion in Structural Biology, vol. 44, pp. 1-8.


Document type: Journal Article
Collection: Journal Articles

Title Antibody recognition of aberrant glycosylation on the surface of cancer cells
Author(s) Soliman, C
Yuriev, E
Ramsland, P
Year 2017
Journal name Current Opinion in Structural Biology
Volume number 44
Start page 1
End page 8
Total pages 8
Publisher Elsevier
Abstract Carbohydrate-binding antibodies and carbohydrate-based vaccines are being actively pursued as targeted immunotherapies for a broad range of cancers. Recognition of tumor-associated carbohydrates (glycans) by antibodies is predominantly towards terminal epitopes on glycoproteins and glycolipids on the surface of cancer cells. Crystallography along with complementary experimental and computational methods have been extensively used to dissect antibody recognition of glycan epitopes commonly found in cancer. We provide an overview of the structural biology of antibody recognition of tumor-associated glycans and propose potential rearrangements of these targets in the membrane that could dictate the complex biological activities of these antibodies against cancer cells.
Subject Structural Biology (incl. Macromolecular Modelling)
Tumour Immunology
DOI - identifier 10.1016/j.sbi.2016.10.009
Copyright notice © 2016 Elsevier Ltd. All rights reserved.
ISSN 0959-440X
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